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研究所について 研究所について 研究所について TOPへ 研究所概要 理念と基本方針 情報の公開について 交通案内 研究所・OICの紹介PDF フロア案内 閉じる 各部のご紹介 各部のご紹介 各部のご紹介 TOPへ 分子薬理部 細胞生物学部 分子病態部 病態ゲノム医学部 血管生理学部 心臓生理機能部 心不全病態制御部 心血管老化制御部 人工臓器部 循環動態制御部 先端医療技術開発部 心臓再生制御部 研究推進支援部 予防医学・疫学情報部 医学統計研究部 心血管モザイク研究室 バイオデジタルツイン研究部 閉じる 研究所紹介PDF フロアマップ 国立循環器病研究センター 病院 研究所 OIC オープンイノベーションセンター 実施中の臨床研究 職員募集 調達情報 交通案内 サイトマップ 背景色 白 黒 ENGLISH 交通案内 メニュー 国立循環器病研究センター 研究所 TOP 各部のご紹介 心臓生理機能部 業績 心臓生理機能部 業績 研究内容 スタッフ 部の業績 2022年の業績 Stainsby AV, PLJ DeKoninck, KJ Crossley, A Thiel, MJ Wallace, JT Pearson, AJ Kashyap, MK Croughan, BA Allison, R Hodges, M Thio, AW Flemmer, AB te Pas, SB Hooper, EV McGillick, MJ Kitchen. Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology. Anatomical Record. Accepted 19 Dec, 2022.Lao JC, CB Bui, MA Pang, SX Cho, I Rudloff, K Elgass, J Schröder, A Maksimenko, NE Mangan, MR Starkey, EM Skuza, YBY Sun, F Beker, CL Collins, OF Kamlin, K König, A Malhotra, K Tan, C Theda, MJ Young, CA McLean, NJ Wilson, A Sehgal, PM Hansboro, JT Pearson, JM Polo, A Veldman, PJ Berger, CA Nold-Petry, MF Nold. Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants. Sci Transl Med 14:eaaz8454, 2022.Tokudome T, K Otani, Y Mao, LL Jensen, Y Arai, T Miyazaki, T Sonobe, JT Pearson, T Osaki, N Minamino, J Ishida, A Fukamizu, H Kawakami, D Onozuka, K Nishimura, M Miyazato, H Nishimura. Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension 79(7):1409-1422, 2022.Sonobe T, H Tsuchimochi, H Maeda, JT Pearson. Increased contribution of KCa channels to muscle contraction induced vascular and blood flow responses in sedentary and exercise trained ZFDM rats. J Physiol 600(12):2919-2938, 2022.Martherus T, MK Croughan, KJ Crossley, MJ Wallace, EV McGillick, M Thio, CC Roehr, JT Pearson, K Lee, G Ruben, MJ Kitchen, AB te Pas, SB Hooper. Higher CPAP levels improve functional residual capacity at birth in preterm rabbits. Pedatric Res 91(7):1686-1694, 2022.Sonobe T, T Akiyama, JT Pearson. Transporter-dependent uptake and metabolism of myocardial interstitial serotonin in the rat heart. J Physiol Sci 72(1);27, 2022.Szulcek R, CN Johnson, JT Pearson, V Sequeira. Bridging techniques: Basic science of molecules, cellular systems, and whole-organ physiology. Frontiers in Physiology 13:879396, 2022.Waddingham MT, H Tsuchimochi, T Sonobe, R Asano, H Jin, CPC Ow, DO Schwenke, R Katare, K Aoyama, K Umetani, M Hoshino, K Uesugi, M Shirai, T Ogo, JT Pearson. Using synchrotron radiation imaging techniques to elucidate the actions of hexarelin in the heart of small animal models. Front Physiol. 12;766818, 2022.Noe KM, Ngo JP, MZL Zhu, A Martin, M Ollason, AD Cochrane, JA Smith, AG Thrift, RG Evans. Intraoperative renal hypoxia and risk of cardiac surgery-associated acute kidney injury. Clin Exper Pharmacol Physiol. 49(2);228-241, 2022.Evans RG, AD Cochrane, SG Hood, N Iguchi, B Marino, R Bellomo, PR McCall, N Okazaki, JA Smith, MZ Zhu, JP Ngo, KM Noe, A Martin, AG Thrift, YR Lankadeva, CN May. Dynamic responses of renal oxygenation at the onset of cardiopulmonary bypass in sheep and man. Perfusion. 37(6);624-632, 2022. 2021年の業績 Pearson JT, HP Thambyah, MT Waddingham, T Inagaki, V Sukumaran, JP Ngo, CPC Ow, T Sonobe, YC Chen, AJ Edgley, Y Fujii, C-K Du, D-Y Zhan, K Umetani, DJ Kelly, H Tsuchimochi, M Shirai. Beta-blockade prevents coronary macro and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat. Clinical Sci. 135(2);327-346, 2021.Sonobe T, T Akiyama, JT Pearson. Carrier-mediated serotonin efflux induced by pharmacological anoxia in the rat heart in vivo. Clin Exp Pharmacol Physiol. 48:1685-1692, 2021.Inocencio I, NT Tran, S Nakamura, SJ Khor, M Wiersma, K Stoecker, A Maksimenko, GR Polglase, DW Walker, JT Pearson, FY Wong. Cerebral haemodynamic response to somatosensory stimulation in preterm and 7-10-day old term lambs: direct synchrotron microangiography assessment. J Cerebral Blood Flow Metab. 42(2):315-328, 2021.Rabaglino MB, M. Wakabayashi, JT Pearson, LL Jensen. Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice. Mechanisms of Ageing and Development 200;111594, 2021.Inagaki T, JT Pearson, H Tsuchimochi, DO Schwenke, S Saito, T Higuchi, T Masaki, K Umetani, M Shirai, Y Nakaoka. Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography. Am J Physiol Heart Circ Physiol 320(3);H1021-H1036, 2021.Pearson JT, HP Thambyah, MT Waddingham, T Inagaki, V Sukumaran, JP Ngo, CPC Ow, T Sonobe, YC Chen, AJ Edgley, Y Fujii, C-K Du, D-Y Zhan, K Umetani, DJ Kelly, H Tsuchimochi, M Shirai. Beta-blockade prevents coronary macro and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat. Clinical Science 135(2);327-346, 2021.Masaki T, M Okazawa, R Asano, T Inagaki, T Ishibashi, A Yamagishi, S Mizushima, M Nishimura, Y Manabe, H Ishibashi-Ueda, M Shirai, H Tsuchimochi, JT Pearson, A Kumanogoh, Y Sakata, T Ogo, T Kishimoto, Y Nakaoka. Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci USA 118(11);e2023899118, 2021.Saw EL, JT Pearson, DO Schwenke, PE Munasinghe, H Tsuchimochi, S Rawai, S Coffey, P Davis, R Bunton, I Van-Hout, Y Kai, MJA Williams, Y Kakinuma, M Fronius, R Katare. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovasc Diabetol 20;50, 2021.Sonobe T, T Akiyama, JT Pearson. Carrier-mediated serotonin efflux induced by pharmacological anoxia in the rat heart in vivo. Clin Exper Pharmacol Physiol 48;1685-1692, 2021.Abe I, T Terabayashi, K Hanada, H Kondo, Y Teshima, Y Ishii, M Miyoshi, S Kira, S Saito, H Tsuchimochi, M Shirai, K Yufu, M Arakane, T Daa, D Thumkeo, S Narumiya, N Takahashi, T Ishizaki. Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction. Cardiovasc Res. 117;1103-1117, 2021.Ngo JP, KM Noe, A Martin, MZL Zhu, AD Cochrane, JA Smith, AG Thrift, RG Evans. Intra-operative and early post-operative prediction of cardiac surgery-associated acute kidney injury: Urinary oxygen tension compared with plasma and urianary biomarkers. J Cardiac Surgery. 36;3577-3585, 2021.Ow CPC, A Trask-Marino, A Betrie, RG Evans, CN May, YR Lankadeva. Targeting oxidative stress in septic acute kidney injury: from theory to practice. J Clin Med. 10(17);3798, 2021.Matsumura T, H Hashimoto, M Sekimizu, AM Saito, Y Iwata, M Asakura, K Kimura, T Tamura, M Funato, K Segawa, K Ogata, T Nakajima. Study protocol for a multicenter, open-label, single-arm study of tranilast for cardiomyopathy of muscular dystrophy. Kurume Med J. 66;121-126, 2021. 2019～2020年の業績 Sukumaran V, H Tsuchimochi, T Sonobe, MT Waddingham, M Shirai, JT Pearson. Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet. Cardiovasc Diabetol. 19:24, 2020.Kawada T, Y Sata, T Akiyama, S Shimizu, T Sonobe, JT Pearson, M Sugimachi. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 225:102657, 2020.Sonobe T, CK Du, T Akiyama, JT Pearson. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiological Reports 7(22):e14297, 2019.Kakehi K, Y Iwanaga, H Watanabe, T Sonobe, T Akiyama, S Shimizu, H Yamamoto, S Miyazaki. Modulation of sympathetic activity and innervation with chronic ivabradine and β-blocker therapies: Analysis of hypertensive rats with heart failure. J Cardiovasc Pharmacol Ther. 24(4):387-396, 2019.Yoshimoto M, Y Onishi, N Mineyama, S Ikegame, M Shirai, JW Osborn, K Miki. Renal and lumbar sympathetic nerve activity during development of hypertension in Dahl salt-sensitive rats. Hypertension 74:888-895, 2019.Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Central activation of cardiac vagal nerve by α2-adrenergic stimulation in impaired in streptozotocin-induced type 1 diabetic rats. Auton Neurosci 216:39-45, 2019.Wilmanns JC, R Pandey, O Hon, A Chandran, JM Schilling, E Forte, Q Wu, G Cagnone, P Bais, V Phillip, D Coleman, H Kocalis, SK Archer, JT Pearson, M Ramialison, J Heineke, HH Patel, NA Rosenthal, MB Furtado, MW Costa. Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism. 20:102-114, 2019.Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci.218:25-30, 2019.Sukumaran V, H Tsuchimochi, T Sonobe, M Shirai, JT Pearson. Liraglutide improves renal endothelial function in obese Zucker rats on a high salt diet. J Pharmacol Exp Ther 369(3):375-388, 2019.Bui CB, M Kolodziej, E Lamanna, K Elgass, A Sehgal, I Rudloff, DO Schwenke, H Tsuchimochi, MAGM Kroon, SX Cho, A Maksimenko, M Cholewa, PJ Berger, MJ Young, JE Bourke, JT Pearson, MF Nold, CA Nold-Petry. Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension. Front Immunol 10:1480, 2019.Nagano K, C Kwon, J Ishida, T Hashimoto, JD Kim, N Kisikawa, M Murao, K Kimura, Y Kasuya, S Kimura, YC Chen, H Tsuchimochi, M Shirai, JT Pearson, A Fukamizu. Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction. J Biochem 166(5):283-392, 2019.Waddingham MT, T. Sonobe, H. Tsuchimochi, A.J. Edgley, V. Sukumaran, Y-C Chen, S.S. Hansra, D.O. Schwenke, K. Umetani, K. Aoyama, N. Yagi, D.J. Kelly, S. Gaderi, M. Herwig, D. Kolijn, A. Mügge, W.J. Paulus, T. Ogo, M. Shirai, N. Hamdani, J.T. Pearson. Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model. J. Mole. Cell Cardiol. 137:119-131, 2019.Pearson JT, M Shirai, V Sukumaran, CK Du, H Tsuchimochi, T Sonobe, MT Waddingham, R Katare, DO Schwenke. Ghrelin and vascular protection. Vascular Biology 1:H97-H102, 2019.Honda M, H Tsuchimochi, K Hitachi, S Ohno. Transcriptional cofactor Vgll2 is required for functional adaptations of skeletal muscle induced by chronic overload. J Cell Physiol. 234(9):15809-15824, 2019. 2018年の業績 Pearson, J.T., N. Collie, R.R. Lamberts, T. Inagaki, M. Yoshimoto, K. Umetani, P. Davis, G. Wilkins, P.P. Jones, M. Shirai, D.O. Schwenke. Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology 159(4):1763-1773, 2018.Khan, Z., J.P. Ngo, B. Le, R.G. Evans, J.T. Pearson, B. Gardiner, D.Smith. Three-dimensional morphometric analysis of the renal vasculature. Am J Physiol Renal Physiol 314(5):F715-F725, 2018.Katayama, K., T. Sakamoto, K. Saito, H. Tsuchimochi, H. Kaiya, T. Watanabe, J.T. Pearson, Y. Takei. Drinking by amphibious fish: convergent evolution of thirst mechanisms during vertebrate terrestrialization. Sci. Rep. 8(1):625, 2018.Katare, R., J.T. Pearson, J.K.S. Lew, M. Wei, H. Tsuchimochi, C.K. Du, D.Y. Zhan, K. Umetani, M. Shirai, D.O. Schwenke. Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Front. Physiol. 9:696, 2018.Sukumaran, V., H. Tsuchimochi, Y. Fujii, H. Hosoda, K. Kangawa, T. Akiyama, M. Shirai, J.T. Pearson. Ghrelin pre-treatment attenuates local oxidative stress and end-organ damage during cardiopulmonary bypass in anesthetized rats. Front. Physiol. 9:196, 2018.Takeshita H, K. Yamamoto, S Nozato, M Takeda, SI Fukada, T Inagaki, H Tsuchimochi, M Shirai, Y Nozato, T Fujimoto, Y Imaizumi, S Yokoyama, M Nagasawa, G Hamano, K Hongyo, T Kawai, H Hanasaki-Yamamoto, S Takeda, T Takahashi, H Akasaka, N Itoh, Y Takami, Y Takeya, K Sugimoto, H Nakagami, H Rakugi. Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice. J Cachexia Sarcopenia Muscle 9:975-986, 2018. 過去の業績2017年の業績2016年の業績2015年の業績2014年の業績2013年の業績2012年の業績2011年以前の業績については業績年報よりご覧ください。 最終更新日：2023年02月03日 各部の紹介About 分子薬理部 細胞生物学部 分子病態部 病態ゲノム医学部 血管生理学部 心臓生理機能部 心不全病態制御部 心血管老化制御部 人工臓器部 循環動態制御部 先端医療技術開発部 心臓再生制御部 研究推進支援部 予防医学・疫学情報部 医学統計研究部 心血管モザイク研究室 バイオデジタルツイン研究部 国立循環器病研究センター 国循について 医療人の育成 循環器病の研究推進 広報活動 ご寄付のお願い 病院 病院について 診療科・部門 看護部 患者の皆様へ 医療関係の皆様へ 研究所 研究所について 各部の紹介 研究所紹介PDF フロアマップ OICオープンイノベーションセンター オープンイノベーションセンター(OIC)について サイエンスカフェについて (法人番号3120905003033) 〒564-8565 大阪府吹田市岸部新町6番1号 TEL：0570-012-545 調達情報 国循　市民公開講座 情報公開・公表事項 職員募集サイト 個人情報の取り扱いについて 実施中の臨床研究 交通案内 このサイトの利用について プライバシーポリシー サイトに関するお問い合わせ 関連リンク Copyright © National Cerebral and Cardiovascular Center All rights reserved. 設定メニュー 文字サイズ 標準 大きく 背景色 白 黒 日本語 English